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Research progress of circumferential tracheal reconstruction via tissue-engineered trachea / 中华外科杂志
Chinese Journal of Surgery ; (12): 104-109, 2022.
Article in Chinese | WPRIM | ID: wpr-935586
ABSTRACT
Tissue engineering, as a new technology, provides a new avenue for the reconstruction of circumferential tracheal defects, which has always been a tremendous challenge for surgeons around the world. Recently, technologies such as decellularization, 3-dimensional printing, electrospinning and cell sheet have significantly enhanced the chondrification. Implantation of epithelial cells or transplantation of epithelial cell sheets also has accelerated the process of epithelialization. And pedicle muscle flap proved to be a reliable strategy for vascularization of tissue-engineered trachea. But it is still a huge challenge to achieve circumferential tracheal functional reconstruction. The key difficulty lies in how to simultaneously realize the functional regeneration of cartilage, blood vessels and epithelial tissues of tissue-engineered trachea. Therefore, how to integrate the above schemes and finally realize segmental tracheal reconstruction needs further research. This article reviews the research progress of repairing circumferential tracheal defects based on tissue engineering technology.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Trachea / Plastic Surgery Procedures / Tissue Engineering / Tissue Scaffolds / Printing, Three-Dimensional Language: Chinese Journal: Chinese Journal of Surgery Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Trachea / Plastic Surgery Procedures / Tissue Engineering / Tissue Scaffolds / Printing, Three-Dimensional Language: Chinese Journal: Chinese Journal of Surgery Year: 2022 Type: Article