Research advances on mesenchymal stem cell-derived extracellular vesicles in promoting angiogenesis of diabetic ulcers / 中华烧伤杂志
Chinese Journal of Burns
;
(6): 393-399, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-936025
ABSTRACT
Extracellular vesicles are nanoparticles secreted by most eukaryotic cells and play important roles in material transport and information transmission between cells, involved in inflammation, angiogenesis, antigen presentation, cell apoptosis, cell differentiation, and other biological processes. The culture supernatant of mesenchymal stem cells is rich in extracellular vesicles, and the extracellular vesicles can regulate the formation of new blood vessels, a key step in wound healing and tissue repair. The persistence of diabetic ulcers is closely related to the blocked formation of wound vascular network. This article reviews the role of extracellular vesicles derived from mesenchymal stem cells in promoting angiogenesis of diabetic ulcers, in order to provide a new idea for the treatment of diabetic ulcers.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ulcer
/
Wound Healing
/
Diabetes Complications
/
Diabetes Mellitus
/
Mesenchymal Stem Cells
/
Extracellular Vesicles
/
Neovascularization, Pathologic
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Burns
Year:
2022
Type:
Article
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