Strategies for Manipulating T Cells in Cancer Immunotherapy
Biomolecules & Therapeutics
; : 299-308, 2022.
Article
in En
| WPRIM
| ID: wpr-937238
Responsible library:
WPRO
ABSTRACT
T cells are attractive targets for the development of immunotherapy to treat cancer due to their biological features, capacity of cytotoxicity, and antigen-specific binding of receptors. Novel strategies that can modulate T cell functions or receptor reactivity provide effective therapies, including checkpoint inhibitor, bispecific antibody, and adoptive transfer of T cells transduced with tumor antigen-specific receptors. T cell-based therapies have presented successful pre-clinical/clinical outcomes despite their common immune-related adverse effects. Ongoing studies will allow us to advance current T cell therapies and develop innovative personalized T cell therapies. This review summarizes immunotherapeutic approaches with a focus on T cells. Anti-cancer T cell therapies are also discussed regarding their biological perspectives, efficacy, toxicity, challenges, and opportunities.
Full text:
1
Index:
WPRIM
Language:
En
Journal:
Biomolecules & Therapeutics
Year:
2022
Type:
Article