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Antibiotic resistance pattern of Pseudomonas aeruginosa wound isolates among Chinese burn patients: A systematic review and meta analysis
Asian Pacific Journal of Tropical Medicine ; (12): 17-25, 2022.
Article in Chinese | WPRIM | ID: wpr-939471
ABSTRACT

Objective:

To investigate the resistance profiles to antimicrobial agents of wound-isolated Pseudomonas (P.) aeruginosa among Chinese burn patients.

Methods:

Electronic databases and manual search were used to identify eligible studies published since 2010. The objectives were pooled resistance rates for eleven common antimicrobial agents, estimated by a random-effects model. Subgroup analyses were conducted by stratifying the studies into three four-year periods based on year of isolation.

Results:

A total of 35 studies were included. Gentamicin had the highest pooled resistance rate (56%, 95% CI 48%-64%), while meropenem had the lowest pooled resistance rate (29%, 95% CI 20%-40%). There was an increasing trend of resistance to common antimicrobial agents of wound-isolated P. aeruginosa over a span of twelve years (2009-2020). There remained the highest risk of gentamicin resistance over time in China. Subgroup analyses indicated significantly higher resistances to ceftazidime and levofloxacin from 2017 to 2020.

Conclusions:

Enhanced resistance to common antimicrobial agents in wound-isolated P. aeruginosa presents a challenge in burn wound management in mainland China. Effective stewardship programs should be established based on corresponding resistance profiles, thereby optimizing treatment options for hospitalized burn patients.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline / Prognostic study / Systematic reviews Language: Chinese Journal: Asian Pacific Journal of Tropical Medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline / Prognostic study / Systematic reviews Language: Chinese Journal: Asian Pacific Journal of Tropical Medicine Year: 2022 Type: Article