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Histone methylation and diabetic cardiomyopathy / 生理学报
Acta Physiologica Sinica ; (6): 461-468, 2022.
Article in Chinese | WPRIM | ID: wpr-939580
ABSTRACT
Histone methylation is one of the key post-translational modifications that plays a critical role in various heart diseases, including diabetic cardiomyopathy. A great deal of evidence has shown that histone methylation is closely related to hyperglycemia, insulin resistance, lipid and advanced glycation end products deposition, inflammatory and oxidative stress, endoplasmic reticulum stress and cell apoptosis, and these pathological factors play an important role in the pathogenesis of diabetic cardiomyopathy. In order to provide a novel theoretical basis and potential targets for the treatment of diabetic cardiomyopathy from the perspective of epigenetics, this review discussed and elucidated the association between histone methylation and the pathogenesis of diabetic cardiomyopathy in details.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Histones / Protein Processing, Post-Translational / Oxidative Stress / Diabetes Mellitus / Diabetic Cardiomyopathies / Methylation Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Histones / Protein Processing, Post-Translational / Oxidative Stress / Diabetes Mellitus / Diabetic Cardiomyopathies / Methylation Limits: Humans Language: Chinese Journal: Acta Physiologica Sinica Year: 2022 Type: Article