MicroRNA-125b Accelerates and Promotes PML-RARa-driven Murine Acute Promyelocytic Leukemia / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 485-493, 2022.
Article
in English
| WPRIM
| ID: wpr-939586
ABSTRACT
Objective@#Most acute promyelocytic leukemia cases are characterized by the PML-RARa fusion oncogene and low white cell counts in peripheral blood.@*Methods@#Based on the frequent overexpression of miR-125-family miRNAs in acute promyelocytic leukemia, we examined the consequence of this phenomenon by using an inducible mouse model overexpressing human miR-125b.@*Results@#MiR-125b expression significantly accelerates PML-RARa-induced leukemogenesis, with the resultant induced leukemia being partially dependent on continued miR-125b overexpression. Interestingly, miR-125b expression led to low peripheral white cell counts to bone marrow blast percentage ratio, confirming the clinical observation in acute promyelocytic leukemia patients.@*Conclusion@#This study suggests that dysregulated miR-125b expression is actively involved in disease progression and pathophysiology of acute promyelocytic leukemia, indicating that targeting miR-125b may represent a new therapeutic option for acute promyelocytic leukemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Leukemia, Promyelocytic, Acute
/
Oncogene Proteins, Fusion
/
MicroRNAs
Limits:
Animals
/
Humans
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2022
Type:
Article
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