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Chinese Medicine Regulates DNA Methylation to Treat Haematological Malignancies: A New Paradigm of "State-Target Medicine" / 中国结合医学杂志
Chinese journal of integrative medicine ; (12): 560-566, 2022.
Article in English | WPRIM | ID: wpr-939775
ABSTRACT
Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies (HMs). Targeted therapy, aiming for DNA methylation, is an effective mainstay of modern medicine; however, many issues remain to be addressed. The progress of epigenetic studies and the proposed theory of "state-target medicine" have provided conditions to form a new treatment paradigm that combines the "body state adjustment" of CM with targeted therapy. We discussed the correlation between Chinese medicine (CM) syndromes/states and DNA methylation in this paper. Additionally, the latest research findings on the intervention and regulation of DNA methylation in HMs, including the core targets, therapy status, CM compounds and active components of the Chinese materia medica were concisely summarized to establish a theoretical foundation of "state-target synchronous conditioning" pattern of integrative medicine for HMs, simultaneously leading a new perspective in clinical diagnosis and therapy.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Drugs, Chinese Herbal / Materia Medica / Hematologic Neoplasms / DNA Methylation / Medicine, Chinese Traditional Type of study: Diagnostic study Limits: Humans Language: English Journal: Chinese journal of integrative medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Drugs, Chinese Herbal / Materia Medica / Hematologic Neoplasms / DNA Methylation / Medicine, Chinese Traditional Type of study: Diagnostic study Limits: Humans Language: English Journal: Chinese journal of integrative medicine Year: 2022 Type: Article