Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells
Protein & Cell
;
(12): 476-489, 2022.
Article
in English
| WPRIM
| ID: wpr-939867
ABSTRACT
Cell therapy approaches that employ engineered mammalian cells for on-demand production of therapeutic agents in the patient's body are moving beyond proof-of-concept in translational medicine. The therapeutic cells can be customized to sense user-defined signals, process them, and respond in a programmable and predictable way. In this paper, we introduce the available tools and strategies employed to design therapeutic cells. Then, various approaches to control cell behaviors, including open-loop and closed-loop systems, are discussed. We also highlight therapeutic applications of engineered cells for early diagnosis and treatment of various diseases in the clinic and in experimental disease models. Finally, we consider emerging technologies such as digital devices and their potential for incorporation into future cell-based therapies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genetic Engineering
/
Gene Regulatory Networks
/
Synthetic Biology
/
Cell Engineering
/
Mammals
Type of study:
Prognostic study
/
Screening study
Limits:
Animals
/
Humans
Language:
English
Journal:
Protein & Cell
Year:
2022
Type:
Article
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