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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy / 医学前沿
Frontiers of Medicine ; (4): 307-321, 2022.
Article in English | WPRIM | ID: wpr-939881
ABSTRACT
The discovery of immune checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an important role in the development of cancer immunotherapy. However, immune-related adverse events often occur because of the enhanced immune response enabled by these agents. Antibiotics are widely applied in clinical treatment, and they are inevitably used in combination with immune checkpoint inhibitors. Clinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpoint inhibitors. Studies have shown that the gut microbiota is essential for the interaction between immune checkpoint inhibitors and antibiotics, although the exact mechanisms remain unclear. This review focuses on the interactions between immune checkpoint inhibitors and antibiotics, with an in-depth discussion about the mechanisms and therapeutic potential of modulating gut microbiota, as well as other new combination strategies.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Programmed Cell Death 1 Receptor / Immune Checkpoint Inhibitors / Immunotherapy / Anti-Bacterial Agents / Neoplasms Type of study: Qualitative research Limits: Humans Language: English Journal: Frontiers of Medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Programmed Cell Death 1 Receptor / Immune Checkpoint Inhibitors / Immunotherapy / Anti-Bacterial Agents / Neoplasms Type of study: Qualitative research Limits: Humans Language: English Journal: Frontiers of Medicine Year: 2022 Type: Article