Breast MR Imaging: Correlation of High Resolution Dynamic MR Findings with Prognostic Factors
Journal of the Korean Radiological Society
; : 355-361, 2005.
Article
in Ko
| WPRIM
| ID: wpr-93990
Responsible library:
WPRO
ABSTRACT
PURPOSE: We wanted to correlate the kinetic and morphologic MR findings of invasive breast cancer with the classical and molecular prognostic factors. MATERIALS AND METHODS: Eighty-seven patients with invasive ductal carcinoma NOS underwent dynamic MR imaging at 1.5 T, and with using the T1-weighted 3D FLASH technique. The morphologic findings (shape, margin, internal enhancement of the mass or the enhancement distribution and the internal enhancement of any non-mass lesion) and the kinetic findings (the initial phase and the delayed phase of the time-signal Intensity curve) were interpreted using a ACR BI-RADS(R)174;-MRI lexicon. We correlate MR findings with histopathologic prognostic factors (tumor size, lymph node status and tumor grade) and the immunohistochemically detected biomarkers (ER, PR, p53, c-erbB-2, EGFR and Ki-67). Univariate and multivariate statistical analyses were then performed. RESULTS: Among the MR findings, a spiculated margin, rim enhancement and washout were significantly correlated with the prognostic factors. A spiculated margin was independently associated with the established predictors of a good prognosis (a lower histologic and nuclear grade, positive ER and PR) and rim enhancement was associated with a poor prognosis (a higher histologic and nuclear grade, negative ER and PR). Wash out was a independent predictor of Ki-67 activity. CONCLUSION: Some of the findings of high resolution dynamic MR imaging were associated with the prognostic factors, and these findings may predict the prognosis of breast cancer.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Prognosis
/
Breast
/
Breast Neoplasms
/
Magnetic Resonance Imaging
/
Biomarkers
/
Carcinoma, Ductal
/
Lymph Nodes
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Humans
Language:
Ko
Journal:
Journal of the Korean Radiological Society
Year:
2005
Type:
Article