A Case of Adult T-cell Leukemia/Lymphoma / 대한피부과학회지
Korean Journal of Dermatology
;
: 58-62, 2007.
Article
in Korean
| WPRIM
| ID: wpr-94040
ABSTRACT
Adult T-cell leukemia/lymphoma (ATLL) is a human malignancy associated with human T-cell leukemia virus type I (HTLV-I), which frequently involves the skin. ATLL can be diagnosed based on clinicopathological findings and the presence of anti-HTLV-I serum antibodies and monoclonal integrated HTLV-I provirus in the DNA of tumor cells. It is characterized by leukemia, lymphadenopathy, hypercalcemia, and lytic bone lesions. We report a case of ATLL in a 59-year-old man who developed multiple, scattered papules on the face and trunk. He had a 3-month history of melena. The physical examination showed multiple cervical and axillary lymph node enlargements. On laboratory investigation, the white blood cell count was 113,900/mm(3) with 70% atypical lymphocytes. Histopathological and immunohistochemical analyses of a skin and stomach biopsy confirmed the diagnosis of T-cell lymphoma. Final diagnosis of ATLL was made based on HTLV-I positivity. The patient underwent multiple cycles of combination chemotherapy and combination therapy of zidovudine and interferon-alpha which produced some improvement, but he died of pulmonary complications 3 months after the initial diagnosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physical Examination
/
Skin
/
Stomach
/
Biopsy
/
DNA
/
Lymphocytes
/
T-Lymphocytes
/
Human T-lymphotropic virus 1
/
Leukemia-Lymphoma, Adult T-Cell
/
Leukemia, T-Cell
Type of study:
Diagnostic study
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2007
Type:
Article
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