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Treatment of Diabetic Nephropathy from Collateral Diseases: A Review / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 265-271, 2022.
Article in Chinese | WPRIM | ID: wpr-940411
ABSTRACT
Diabetic nephropathy (DN) is classified into "collateral diseases" in traditional Chinese medicine (TCM). This study reviewed, analyzed, and discussed the clinical and basic research on DN treatment from collateral diseases in recent years. The main TCM therapeutic principles of DN from collateral diseases are dominated by reinforcing the deficiency and dredging collaterals. Fundamental research showed that the relevant mechanism is related to the improvement of oxidative stress and endoplasmic reticulum stress, reduction of inflammatory responses, coping with microcirculation disorder and vascular endothelial damage, and alleviation of renal injury. The theory of collateral diseases can provide ideas for clinical and basic research on DN and also shows advantages in clinical application. However, the present clinical application of this therapeutic principle is mainly based on the combination of deficiency-reinforcing drugs and blood stasis-resolving drugs. In spite of some overlap, blood stasis syndrome and collateral diseases are not in the same category. Therefore, the current diagnosis and treatment of DN from collateral diseases fail to combine with the changes of collateral vessels, main pathogenic factors, and the changes of the secondary pathogenesis. The application of classic collateral drugs such as pungent drugs, rattan drugs, and insect drugs has not been paid enough attention in syndrome differentiation and treatment. In addition, there is a lack of correlation with clinical symptoms and laboratory indexes in the basic research on the treatment of DN by Chinese medicinal prescriptions. Accordingly, the present study advocates systematic research on DN under the guidance of collateral diseases theory, clarifying the essence of DN in collateral diseases and emphasizing the importance of collateral drugs and microscopic syndrome differentiation in screening target drugs for DN to explore the underlying mechanism of collateral drugs in the treatment of DN, so as to provide evidence for the clinical application of collateral diseases theory and Chinese medicinal prescriptions against collateral diseases in the treatment of DN.

Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Practice guideline Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2022 Type: Article