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Anti-aging Mechanism of Chinese Medicinal Polysaccharides: A Review / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 271-282, 2022.
Article in Chinese | WPRIM | ID: wpr-940544
ABSTRACT
In the greying society, pension burden and high incidence of geriatric diseases have hindered social and economic development to a certain extent. Aging is a biological process involving multiple organs and factors, which leads to the occurrence of a variety of diseases. The occurrence of aging is related to a variety of signal pathways, such as nutrient sensing signal pathway and intracellular stress signal pathway, which attracts the interest of scholars in anti-aging drugs and poses a challenge to the development of such drugs. The anti-tumorhypoglycemic, hypolipidemic, antioxidant, and antiviral activities of Chinese medicinal polysaccharides have been gradually confirmed, and they also have significant advantages in anti-aging. Thus, they are potential candidates for the development of anti-aging drugs. It has been verified that Chinese medicinal polysaccharides exert the anti-aging effect through a variety of mechanisms. To be specific, through dietary restriction, they promote the expression of longevity genes silencing information regulator 1 (Sirt1) and forkhead box O (FoxO) transcription factor, enhance the sensitivity to insulin, activate Sirt1 deacetylase or inhibit insulin/IGF-1 signaling (IIS) and mammalian target of rapamycin (mTOR) signal pathway, thereby exerting the anti-aging effect. In addition, they can inhibit the production of reactive oxygen species (ROS) and the release of pro-inflammatory mediators, enhance anti-inflammatory and antioxidant capacity, and regulate the immunity to inhibit inflammation and aging. Moreover, they can also inhibit apoptosis and delay aging through p53-mediated pathway. Despite the extensive research on anti-aging effect of Chinese medicinal polysaccharides, and the diverse effects and ideal efficacy of the polysaccharides, the anti-aging mechanism has not been systematically reviewed. Therefore, this paper summarizes the relevant literature in PubMed and CNKI and systematically expounds the aging-related signal pathways regulated by Chinese medicinal polysaccharides, which is expected to provide a reference for researchers and clinical workers.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2022 Type: Article