Your browser doesn't support javascript.
loading
Anti-fibrosis Mechanism of Buyang Huanwutang: A Review / 中国实验方剂学杂志
Chinese Journal of Experimental Traditional Medical Formulae ; (24): 268-274, 2022.
Article in Chinese | WPRIM | ID: wpr-940644
ABSTRACT
Fibrosis can occur in nearly all organs of the body and is an outcome of many chronic diseases. As inflammation leads to necrosis of parenchymal cells, excessive proliferation of fibroblasts and overproduction of extracellular matrix (ECM) occur in tissues and organs, which may cause structural damage and loss of function of organs in the case of continuous progression. Chinese medicine has definite effect on fibrosis and prescriptions with effects of replenishing Qi and activating blood, such as Buyang Huanwutang, are frequently used in clinical settings. Clinical research and experiments show that Buyang Huanwutang can delay the progression of fibrosis in multiple organs such as lungheartliver, and kidney by improving organ function, reducing ECM deposition, anti-oxidative stress, anti-inflammatory response, regulating the imbalance of matrix metalloproteinasesMMPs)/tissue inhibitors of metalloproteinases (TIMPs), and modulating transforming growth factor-β (TGF-β)/Smad pathway. According to traditional Chinese medicine, healthy Qi deficiency is the internal cause of fibrosis, and blood stasis is an important pathological factor in the formation of fibrosis. Moreover, deficiency and stasis exist in the whole process of fibrosis and the changes of microenvironment of fibrotic organs and tissues accord with the pathological manifestations of Qi deficiency and blood stasis. This article reviews the anti-fibrosis mechanism of Buyang Huanwutang in multiple organs, which provides a science-based explanation for the treatment of fibrosis by Buyang Huanwutang and lays a foundation for further clinical research.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2022 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Experimental Traditional Medical Formulae Year: 2022 Type: Article