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Relationship between C-reactive protein level and incidence of left atrial spontaneous echocardiographic contrast in patients with nonvalvular atrial fibrillation / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 223-227, 2020.
Article in Zh | WPRIM | ID: wpr-941095
Responsible library: WPRO
ABSTRACT
Objective: To investigate the relationship between high sensitivity C-reactive protein (hs-CRP) level and incidence of left atrial spontaneous echocardiographic contrast (LASEC) in the patients with nonvalvular atrial fibrillation (AF). Methods: Four hundred and ninety consecutive patients with nonvalvular atrial fibrillation who underwent radiofrequency ablation for the first time from January 1, 2018 to June 30, 2018 in the Department of Cardiology, Beijing Anzhen Hospital were enrolled. According to the results of transesophageal echocardiography before radiofrequency ablation, patients were divided into the group without LASEC (n=338) and the group with LASEC (n=152). hs-CRP was determined by latex enhanced immunoturbidimetry. The relationship between hs-CRP and LASEC in patients with nonvalvular atrial fibrillation was investigated by univariate and multivariate logistic analysis. Results: LASEC was detected in 152 (31%) of 490 patients. Significant differences in age, type of atrial fibrillation, previous embolic events, fibrinogen, D-dimer, the left atrial anteroposterior diameter and CHA(2)DS(2)-VASc scores were found between patients with and without LASEC (all P<0.05). Compared with the group without LASEC, the serum hs-CRP level was significantly higher in the group with LASEC (3.16 (1.30, 5.23) mg/L vs. 0.67 (0.37, 1.48) mg/L, P<0.001). Multivariate logistic regression analysis showed that hs-CRP (OR=1.136, 95%CI 1.060 - 1.217, P<0.001) and D-dimer (OR=1.040, 95%CI 1.011 - 1.070, P=0.007) were independent determinants for LASEC in this patient cohort. Conclusions: hs-CRP is an independent determinant for LASEC in patients with nonvalvular atrial fibrillation. Inflammation may thus be involved in the formation of prethrombotic state in patients with nonvalvular atrial fibrillation.
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Full text: 1 Index: WPRIM Main subject: Atrial Fibrillation / C-Reactive Protein / Incidence / Risk Factors / Echocardiography, Transesophageal / Atrial Appendage / Electrocardiography / Heart Atria Type of study: Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: Zh Journal: Chinese Journal of Cardiology Year: 2020 Type: Article
Full text: 1 Index: WPRIM Main subject: Atrial Fibrillation / C-Reactive Protein / Incidence / Risk Factors / Echocardiography, Transesophageal / Atrial Appendage / Electrocardiography / Heart Atria Type of study: Etiology_studies / Incidence_studies / Prognostic_studies / Risk_factors_studies Limits: Humans Language: Zh Journal: Chinese Journal of Cardiology Year: 2020 Type: Article