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Schisandrae Fructus oil-induced elevation in serum triglyceride and lipoprotein concentrations associated with physiologic hepatomegaly in mice
Article in Chinese | WPRIM | ID: wpr-941594
Responsible library: WPRO
ABSTRACT

Objective:

To investigate hypertriglyceridemia and hepatomegaly caused by Schisandrae Sphenantherae Fructus (FSS) and Schisandra chinensis Fructus (FSC) oils in mice.

Methods:

Mice were orally administered a single dose of Schisandrae Fructus oils. Serum and hepatic triglyceride (TG), triglyceride transfer protein (TTP), apolipoprotein B48 (Apo B48), very-low-density lipoprotein (VLDL), hepatocyte growth factor (HGF), alanine aminotransfease (ALT) and liver index were measured at 6-120 h post-dosing.

Results:

FSS and FSC oil caused time and dose-dependent increases in serum and hepatic TG levels, with maximum increases in the liver (by 297% and 340%) at 12 h post-dosing and serum (244% and 439%) at 24-h post-dosing, respectively. Schisandrae Fructus oil treatments also elevated the levels of serum TTP by 51% and 63%, Apo B48 by 152% and 425%, and VLDL by 67% and 38% in mice, respectively. FSS and FSC oil treatments also increased liver mass by 53% and 55% and HGF by 106% and 174%, but lowered serum ALT activity by 38% and 22%, respectively. Fenofibrate pre/ co-treatment attenuated the FSS and FSC oil-induced elevation in serum TG levels by 41% and 49% at 48 h post-dosing, respectively, but increased hepatic TG contents (by 38% and 33%, respectively) at 12 h post-dosing.

Conclusions:

Our findings provide evidence to support the establishment of a novel mouse model of hypertriglyceridemia by oral administration of FSS oil (mainly increasing endogenous TG) and FSC oil (mainly elevating exogenous TG).

Anti-proliferative; Antimicrobial; Applications; Biological activities; Metabolites; Prodigiosin; Serratia; Synthesis; Amphotericin B; Antifungal; Aspergillus fumigatus; Calotropis gigantea; Invasive pulmonary aspergillosis; Mice; Anti-migration; Anti-proliferation; Apoptosis; Eca109; Esophageal cancer; Essential oil; Gas chromatographymass spectrometry; Mitochondrial pathway; Saussurea costus; STAT3; Calcitonin receptor; Dieckol; Eisenia bicyclis; ERK; JNK; NF-κB; NFATc1; Osteoclasts; RANKL; RAW 264.7 cell; TRAP; Autophagy; Cancer cell; Copper; Iron; Prooxidant; Syringic acid; Carvacrol; Crocin; Hepatoprotective; Inflammatory; NF-κB; Nrf2; Oxidative stress; Reno-protective; Thymoquinone; Apoptosis; Humulus japonicus; MAPK; Nrf2; Oxidative stress; Parkinson's disease; PC12 cells; Atherosclerosis; Cell viability; Fucoxanthin; HUVEC; Inflammation; NF-κB; Nrf2 signaling pathway; Oxidative stress; Oxidized low-density lipoprotein; Cellular mechanisms; Cytotoxicity; Giardiasis; Herbal medicines; Infectious diarrhea; Microbiology; Shigellosis; Terfezia claveryi; Acrylamide; Apoptosis; Inflammation; Naringin; Nephrotoxicity; Oxidative DNA damage; Oxidative stress; Antiatherosclerosis; Cardio-protection; Cardiovascular diseases; Gastrodia elata Blume; Gastrodin; Myocardial ischemia-reperfusion injury; Anti-adipogenesis; Antihyperlipidemic; Extract; Flavonoids; Hyperlipidemia; Lipid-lowering effect; Mice; Oroxylum indicum; Volatile oils; Analgesic; Biological products; Essential oil; Monoterpene; Opioid; Pain; Perillyl acetate; Antiobesity; Antioxidant; DPPH; Metabolite profiling; Mice; Hypolipidemic; Molecular docking; Pancreatic lipase; Solanum nigrum; Total antioxidant power; Total flavonoid content; Total phenolic contents; UHPLC-QTOF-MS/MS; Ultrasonication; Apoptosis; Breast cancer; Cell cycle; Mangifera pajang; Methyl gallate; Oxidative stress; -catenin; Bone formation; MC3T3-E1; Osteoblast differentiation; Protaetia brevitarsis; Cardiac injury; Cardiotoxicity; Chemoprevention; Doxorubicin; Genistein; Hemodynamic changes; Phloretin; Phytoestrogens; Apoptosis; Autophagy; Endoplasmic reticulum stress; Halymenia durvillei; Hexadecanoic acid; Red algae; Triple-negative breast cancer; Dipeptidyl peptidase-4 inhibitors; Farnesoid X receptor agonists; Glucagon-like peptide-1 analogues; Insulin sensitizers; Non-alcoholic fatty liver disease; Steatosis; Anticoagulant; Antioxidant; Antiplatelet; Extract; Kenaf seed; Oxidative stress; Protein; Alanine aminotransferase; Hepatomegaly; Hypertriglyceridemia; Mouse model; Schisandrae Fructus oils; Triglyceride
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Asian Pacific Journal of Tropical Medicine Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Asian Pacific Journal of Tropical Medicine Year: 2022 Type: Article