Effectiveness of Topical Chia Seed Oil on Pruritus of End-stage Renal Disease (ESRD) Patients and Healthy Volunteers
Annals of Dermatology
;
: 143-148, 2010.
Article
in English
| WPRIM
| ID: wpr-94331
ABSTRACT
BACKGROUND:
Several studies have been performed to evaluate the efficacy of dietary n-3 fatty acid for patients with renal dysfunction. While about 40% to 80% of patients with end-stage renal disease (ESRD) complain about pruritus and xerosis, there are few reports on the effects of topical n-3 fatty acid on these symptoms.OBJECTIVE:
In order to investigate the possible beneficial effects of topical n-3 fatty acid, oils extracted from chia (Salvia hispanica) seed were formulated into topical products, the effects of which were measured.METHODS:
Five healthy volunteers having xerotic pruritus symptoms and 5 patients with pruritus caused by either ESRD or diabetes were involved in this study. A topical formulation containing 4% chia seed oils were applied for an 8-week duration. Subjective itching symptoms were assessed on a 6-point scale, as were other skin functions, namely transepidermal water loss and skin capacitance.RESULTS:
After the 8 weeks of application, significant improvements in skin hydration, lichen simplex chronicus, and prurigo nodularis were observed in all patients. A similar improvement was also observed among healthy volunteers with xerotic pruritus. Improvement of epidermal permeability barrier function and skin hydration, represented by trans-epidermal water loss and skin capacitance, respectively, were also observed. No adverse effects were observed in all the tested patients and volunteers.CONCLUSION:
Chia seed oil can be used as an adjuvant moisturizing agent for pruritic skin, including that of ESRD patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Permeability
/
Polystyrenes
/
Prurigo
/
Pruritus
/
Seeds
/
Skin
/
Water Loss, Insensible
/
Oils
/
Fatty Acids, Omega-3
/
Alpha-Linolenic Acid
Limits:
Humans
Language:
English
Journal:
Annals of Dermatology
Year:
2010
Type:
Article
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