Relaxant Effects of Thiopental, Ketamine, and Propofol on Isolated Rat Tracheal smooth Muscle / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 727-733, 2001.
Article
in Korean
| WPRIM
| ID: wpr-94421
ABSTRACT
BACKGROUND:
Intravenous anesthetics may modify airway responsiveness. The author investigated the relaxant effect of thiopental, ketamine, and propofol on isolated rat tracheal smooth muscles.METHODS:
The trachea of the rat was dissected and cut into 3-mm rings. The rings were mounted in a water-jacked organ bath filled with Krebs solution aerated with 95% O2 and 5% CO2 at 37degreesC. Thiopental, ketamine, and propofol were given randomly to each ring preconstricted with EC50 of acetylcholine from 10(-6) to 10(-3) M. The relaxation response was the tension during anesthetic equilibration, expressed as a percentage of the tension from EC50 of acetylcholine.RESULTS:
Thiopental and propofol (10(-5) to 10(-3) M) relaxed acetylcholine-induced contractions in a dose dependent manner (P < 0.05). Ketamine in doses of 10(-5) and 10(-4) M constricted acetylcholine-induced contractions by 3.2% and 16.5% respectively (P < 0.05). But ketamine in a dose of 10(-3) relaxed acetylcholine-induced contractions by 76.4% (P < 0.05). The relaxation of tracheal smooth muscles was greatest in thiopental, and was least in ketamine (P < 0.05).CONCLUSIONS:
All three intravenous anesthetics have an excellent relaxation of tracheal smooth muscles in rats, except in doses of 10(-5) and 10(-4) M of ketamine.
Full text:
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Index:
WPRIM (Western Pacific)
Main subject:
Relaxation
/
Thiopental
/
Trachea
/
Baths
/
Acetylcholine
/
Propofol
/
Anesthetics, Intravenous
/
Ketamine
/
Muscle, Smooth
Limits:
Animals
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2001
Type:
Article
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