Methanolic extract of Abrus precatorius promotes breast cancer MDA-MB-231 cell death by inducing cell cycle arrest at G
Asian Pacific Journal of Tropical Biomedicine
;
(12): 249-256, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-950359
ABSTRACT
Objective:
To determine the anti-proliferative activity of Abrus precatorius (A. precatorius) leaf extracts and their effect on cell death.Methods:
A. precatorius leaves were extracted successively with hexane, ethyl acetate and methanol by Soxhlet extraction. Aqueous extract was prepared by decoction at 50 C. Extracts of A. precatorius leaves were used to treat selected cancer and normal cell lines for 72 h. Furthermore, 3-(4,5-dimethyl thiazol-2-yl) 2,5-diphenyl tetrazolium bromide assay was performed to determine cell viability. Analysis of cell cycle arrest, apoptosis assay and apoptosis protein expressions were determined by flow cytometry.Results:
Methanolic extract of A. precatorius leaves showed the lowest IC
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2019
Type:
Article
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