Physicochemical properties, antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids
Asian Pacific Journal of Tropical Biomedicine
;
(12): 201-206, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-950442
ABSTRACT
Objective:
To study physicochemical properties, antioxidant and anti-inflammatory activities of coumarin-carbonodithioate hybrids.Methods:
The substituted 4-bromomethyl coumarins were synthesized in first step by the cyclization. Then the reaction of substituted coumarins (a-e) with potassium O-ethyl/methyl carbonodithioate (1) by using absolute ethanol as solvent, afforded coumarin-carbonodithioate (1a-1j) derivatives under microwave irradiation and the conventional method. The spectroscopic analysis was used for the characterization of coumarin derivatives. The title (1a-1j) compounds were confirmed by spectroscopic methods. Antioxidant property was evaluated by using DPPH free radical-scavenging ability assay method and anti-inflammatory activity was evaluated by protein denaturation procedure using diclofenac sodium as a standard. Drug-likeness. In-silico toxicity was predicted with LD
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2018
Type:
Article
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