Neurotropic effects of aspartame, stevia and sucralose on memory retention and on the histology of the hippocampus of the ICR mice (Mus musculus)
Asian Pacific Journal of Tropical Biomedicine
;
(12): 114-118, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-950798
ABSTRACT
Objective:
To identify the effects of the consumption of non-nutritive sweeteners on memory retention and on the histology of the hippocampus.Methods:
In this study, 20 mice were used to determine if there is an effect of consuming the maximum allowable dose of the non-nutritive sweeteners on the memory retention and on the histology of the hippocampus. The mice were distributed into four groups and the treatments were given via oral gavage Group 1 (water), Group 2 (aspartame 1. 000 mg/kg), Group 3 (stevia 1. 000 mg/kg) and Group 4 (sucralose 16. 000 mg/kg). Treatments were administered to the different experimental groups for 32 days, after which memory retention was tested using the two-day water maze protocol. After the tests, the mice were sacrificed and the brain was analyzed histologically for neurotrophic effects.Results:
Based on the results of the two-day water maze protocol, there were no differences between the non-nutritive sweeteners and the control group. However, stevia showed high cellular apoptosis followed by aspartame, sucralose and control group.Conclusions:
There was no significant effect on the memory of the mice. It showed histologically however, that stevia had a significant neurotropic effect compared to the other sweeteners.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2016
Type:
Article
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