Evaluation of imatinib mesylate (Gleevec) on KAI1/CD82 gene expression in breast cancer MCF-7 cells using quantitative real-time PCR

Seyed-Ataollah-Sadat SHANDIZ; Amir MIRZAIE; Hamidreza JOUZAGHKAR; Marjan KHOSRAVANI; Sepideh MOHAMMADI; Hassan NOORBAZARGAN; Davoud-Nouri INANLOU; Mojgan-Dalirsaber JALALI; Fahimeh BAGHBANI-ARANI; Behta KESHAVARZ-PAKSERESHT

Seyed-Ataollah-Sadat SHANDIZ; Amir MIRZAIE; Hamidreza JOUZAGHKAR; Marjan KHOSRAVANI; Sepideh MOHAMMADI; Hassan NOORBAZARGAN; Davoud-Nouri INANLOU; Mojgan-Dalirsaber JALALI; Fahimeh BAGHBANI-ARANI; Behta KESHAVARZ-PAKSERESHT.

Asian Pacific Journal of Tropical Biomedicine ; (12): 159-163, 2016.

Article in Chinese | WPRIM | ID: wpr-950809

ABSTRACT

ABSTRACT

Objective:

To evaluate the effect of imatinib mesylate on cell viability, anti cancer effect through modulation of KAI1/CD82 gene expression in breast cancer MCF-7 cell line.

Methods:

The effects of imatinib mesylate on cell viability in MCF-7 cell line were assessed using MTT assay and IC

Breast cancer; Imatinib mesylate; KAI1/CD82; Metastasis; Real-time PCR

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Asian Pacific Journal of Tropical Biomedicine Year: 2016 Type: Article