Effect of pre-existing Schistosoma haematobium infection on Plasmodium berghei multiplications in imprinting control region mice
Asian Pacific Journal of Tropical Biomedicine
;
(12): 488-492, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-950917
ABSTRACT
Objective:
To investigate the effect of pre-existing Schistosoma haematobium (S. haematobium) infection on malaria disease severity.Methods:
The study involved the use of twenty-five imprinting control region mice, fifteen of which were initially infected with S. haematobium. Five of the remaining ten schisto-uninfected mice together with five schisto-infected mice were infected with Plasmodium berghei (P. berghei) after four weeks (acute stage) of schistosoma infection. The remaining five schisto-uninfected mice together with five schisto-infected mice were also infected with P. berghei after seven weeks (chronic stage) of schistosoma infection. The last five schisto-infected mice were used as control group. They were then monitored for changes in P. berghei parasitaemia on Days 3, 5, 7, 9 and 11 post-infection. Records on their survivability were also taken.Results:
The co-infected mice had significantly higher malaria parasitaemia, compared with the mono-infected mice during acute S. haematobium infection. In contrast, the coinfected mice had significantly lower malaria parasitaemia during chronic S. haematobium infection and a higher survival rate.Conclusions:
Co-infection of mice with P. berghei during acute S. haematobium infection resulted in rapid P. berghei development and increased malaria parasitaemia. However, the co-infection resulted in slower P. berghei development and decreased malaria parasitaemia with enhanced survivability of the mice during chronic S. haematobium infection. Therefore, pre-existing chronic S. haematobium infection may provide some protection to the host by reducing parasitaemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS