Inhibitory effect of Thymus vulgaris extract on memory impairment induced by scopolamine in rat
Asian Pacific Journal of Tropical Biomedicine
;
(12): 845-851, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-950970
ABSTRACT
Objective:
To investigate the effect of Thymus vulgaris (. T. vulgaris) on learning and memory functions in scopolamine-induced memory deficit in rats. Memory enhancing activity in scopolamine-induced amnesic rats was investigated by assessing the Morris water maze and passive avoidance paradigm.Methods:
A total of 42 male Wistar rats were divided into 6 equal groups as follow control group received water, scopolamine treated group received scopolamine 1 mg/kg for 15 days, two scopolamine + T. vulgaris treated groups received scopolamine and T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days, two intact groups received T. vulgaris extract 50 and 100 mg/kg body weight per day for 15 days.Results:
Administration of T. vulgaris extract significantly restored memory and learning impairments induced by scopolamine in the passive avoidance test and Morris water maze test.Conclusions:
T. vulgaris extract has repairing effects on memory and behavioral disorders produced by scopolamine and may have beneficial effects in the treatment of Alzheimer's disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Biomedicine
Year:
2015
Type:
Article
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