Clinicopathologic Correlations of E-cadherin and Prrx-1 Expression Loss in Hepatocellular Carcinoma
Journal of Pathology and Translational Medicine
;
: 327-336, 2016.
Article
in English
| WPRIM
| ID: wpr-9510
ABSTRACT
BACKGROUND:
Developing predictive markers for hepatocellular carcinoma (HCC) is important, because many patients experience recurrence and metastasis. Epithelial to mesenchymal transition (EMT) is a developmental process that plays an important role during embryogenesis and also during cancer metastasis. Paired-related homeobox protein 1 (Prrx-1) is an EMT inducer that has recently been introduced, and its prognostic significance in HCC is largely unknown.METHODS:
Tissue microarray was constructed using surgically resected primary HCCs from 244 cases. Immunohistochemical staining of E-cadherin and Prrx-1 was performed. The correlation between E-cadherin loss and Prrx-1 expression, as well as other clinicopathologic factors, was evaluated.RESULTS:
E-cadherin expression was decreased in 96 cases (39.4%). Loss of E-cadherin correlated with a higher recurrence rate (p 40%) were independent prognostic factors for shorter overall survival.CONCLUSIONS:
Prrx-1 was expressed in small portions of HCCs but not in normal livers. Additional studies with a large number of Prrx-1-positive cases are required to confirm the results of this study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Fibrosis
/
Cadherins
/
Proportional Hazards Models
/
Genes, Homeobox
/
Cohort Studies
/
Carcinoma, Hepatocellular
/
Disease-Free Survival
/
Embryonic Development
/
Epithelial-Mesenchymal Transition
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2016
Type:
Article
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