Changes of TIZ expression in epithelial ovarian cancer cells
Asian Pacific Journal of Tropical Medicine
;
(12): 157-161, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-951560
ABSTRACT
Objective:
To study the change of TIZ expression in epithelial ovarian cancer cells.Methods:
HO8910 cells were transinfected with siRNA to inhibit the expression of TIZ. pcDNA3.1-TIZ vectors were combined to increase the TIZ expression level. The cell viability, colony forming efficiency and cycle distribution of HO8910, HO8910/NC, HO8910/pcDNA3.1-NC, HO8910/TIZ-573 and H08910/pcDNA3.1-TIZ were compared, and the invasion rate, migration rate and adhesion rate between 5 groups of cells were compared.Results:
Compared with those of HO8910, HO8910/NC and HO8910/pcDNA3.1-NC, the cell viability, colony forming efficiency and cell cycle distribution of HO8910/TIZ-573 were increased, while the indexes of H08910/pcDNA3.1-NC were decreased with statistical significant difference (. P0.05).Conclusions:
The expression of TIZ can inhibit the proliferation of epithelial ovarian cancer cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2015
Type:
Article
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