Antiviral activity of maca (Lepidium meyenii) against human influenza virus
Asian Pacific Journal of Tropical Medicine
;
(12): S415-S420, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-951720
ABSTRACT
Objective:
To investigate antiviral activity of maca to reduce viral load in Madin-Darby canine kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and Flu-B, respectively).Methods:
Maca were extracted with methanol (12, v/v). The cell viability and toxicity of the extracts were evaluated on MDCK cells using method MTT assay. Antiviral activity of compounds against Flu-A and Flu-B viruses was assayed using a test for determining the inhibition of the cytopathic effect on cell culture and multiplex RT-PCR.Results:
The methanol extract of maca showed low cytotoxicity and inhibited influenza-induced cytopathic effect significantly, while viral load was reduced via inhibition of viral growth in MDCK infected cells. Maca contains potent inhibitors of Flu-A and Flu-B with a selectivity index [cytotoxic concentration 50%/IC
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Asian Pacific Journal of Tropical Medicine
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS