Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice

Zhixin PENG; Zengqiang YUAN; Zhixin PENG; Xiaoheng LI; Yuhao GAO; Zengqiang YUAN; Jun LI; Yuan DONG; Yajin LIAO; Meichen YAN; Zengqiang YUAN; Jinbo CHENG

Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice / 神经科学通报·英文版

Zhixin PENG; Zengqiang YUAN; Zhixin PENG; Xiaoheng LI; Yuhao GAO; Zengqiang YUAN; Jun LI; Yuan DONG; Yajin LIAO; Meichen YAN; Zengqiang YUAN; Jinbo CHENG.

Neuroscience Bulletin ; (6): 1671-1682, 2021.

Article in Chinese | WPRIM | ID: wpr-951934

ABSTRACT

ABSTRACT

Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression. Discs large homolog 1 (Dlg1), an adaptor protein, regulates cell polarization and the function of K

Depression; Dlg1; Microglia; Neuroinflammation

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Neuroscience Bulletin Year: 2021 Type: Article