Circulating levels of interleukin-8 and vascular endothelial growth factor in patients with carotid stenosis
Journal of Korean Medical Science
;
: 198-203, 2001.
Article
in English
| WPRIM
| ID: wpr-95272
ABSTRACT
Interleukin (IL)-8 and vascular endothelial growth factor (VEGF) are important factors that induce the migration and proliferation of endothelial cells, increase the vascular permeability, and the modulate chemotaxis of monocytes. These molecules have been found in human atherosclerotic plaques. However, it is not clear whether the circulating levels of IL-8 and VEGF correlate with the extents of carotid stenosis. In this study, we investigated the relationship between circulating levels of IL-8 as well as VEGF and the extents of carotid stenosis. Sera from 41 patients with carotid stenosis were assessed for concentrations of IL-8 and VEGF by enzyme-linked immunosorbent assay. The degree of stenosis of extracranial carotid artery was calibrated by carotid B- mode ultrasonography. The serum concentration of IL-8 (r=-0.04733, p>0.05) was not correlated with the degree of stenosis. However, the serum concentration of VEGF (r=0.4974, p<0.01) was significantly correlated with the degree of carotid stenosis. These findings suggest that increased serum level of VEGF might be a marker for higher degree of stenosis of extracranial carotid artery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Carotid Artery Diseases
/
Endothelial Growth Factors
/
Interleukin-8
/
Lymphokines
/
Carotid Stenosis
/
Disease Progression
/
Middle Aged
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Journal of Korean Medical Science
Year:
2001
Type:
Article
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