Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition

Xin LI; Xiao-wen JIANG; Hai-xiao CHU; Qing-chun ZHAO; Chao-hong CAI; Huai-wei DING; Xiao-wen JIANG; Xin LI; Xiao-wen JIANG; Hai-xiao CHU; Qing-chun ZHAO; Chao-hong CAI; Huai-wei DING; Xiao-wen JIANG

Neuroprotective effects of kukoamine A on 6-OHDA-induced Parkinson's model through apoptosis and iron accumulation inhibition / 中草药·英文版

Xin LI; Xiao-wen JIANG; Hai-xiao CHU; Qing-chun ZHAO; Chao-hong CAI; Huai-wei DING; Xiao-wen JIANG; Xin LI; Xiao-wen JIANG; Hai-xiao CHU; Qing-chun ZHAO; Chao-hong CAI; Huai-wei DING; Xiao-wen JIANG.

Chinese Herbal Medicines ; (4): 105-115, 2021.

Article in Chinese | WPRIM | ID: wpr-953693

ABSTRACT

ABSTRACT

Objective:

Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in substantia nigra (SN). Our previous study demonstrated kukoamine A (KuA) to exhibit strong neuroprotective effects through antioxidative stress, and autophagy in MPTP/MPP

6-OHDA; iron chelation; iron homeostasis; kukoamine A; neuroprotection; Parkinson's disease

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Herbal Medicines Year: 2021 Type: Article