Progress on the correlation between perinatal hypoxia and autism spectrum disorder / 国际儿科学杂志

ABSTRACT

The global prevalence rate of autism spectrum disorder(ASD)is 1%~1.5%, and the latest prevalence rate in the United States is 1.7%.ASD has become one of the diseases with rapid growth in the number of global diseases.In the past decade, scholars at home and abroad have noticed that hypoxia can regulate the fetal growth trajectory and increase the risk of a variety of neurological diseases, including ASD.This paper focuses on the correlation between perinatal hypoxia and the prevalence of ASD by analyzing hypoxia in epidemiology, the consistency between hypoxia neurobiology and ASD, and the possible mechanism of the association between hypoxia and ASD.Perinatal hypoxia may affect the development of children′s nervous system from epigenetics, dopamine, inflammatory factors, oxidative stress, steroids, and ultimately increase the risk of ASD.It provides an important reference for evaluating pregnancy monitoring indicators and formulating intervention, and evaluates early risk in advance.Early diagnosis and treatment can improve the prognosis of children.