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Progress of IgA antibody class switch in the pathogenesis of IgA nephropathy / 国际儿科学杂志
International Journal of Pediatrics ; (6): 438-442, 2022.
Article in Chinese | WPRIM | ID: wpr-954054
ABSTRACT
IgA nephropathy(IgAN)is a common primary glomerular disease.The abnormal increase of IgA molecules in serum can be regarded as the initiation stage of IgAN development, and the abnormal IgA antibody class switch process in B cells leads to the overproduction of IgA.In order to provide new ideas for the prevention and treatment of IgAN, this paper reviews the role of IgA antibody class switch in the pathogenesis of IgAN from the aspects of mucosal immunity, T cells, cytokines and signaling pathways, as well as possible therapeutic targets.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Pediatrics Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: International Journal of Pediatrics Year: 2022 Type: Article