Advances in single-cell RNA sequencing for Kawasaki disease / 国际儿科学杂志

ABSTRACT

Kawasaki disease, an acute self-limited systematic vasculitis, predominantly affects children under 5 years old.One of the most common complications is coronary artery lesions.Currently, the pathogenesis mechanism of Kawasaki disease is considered to be multifactorial, including genetic susceptibility, impaired immune response, inflammatory injury and so on.Over the past decade, by interpreting the unique gene expression pattern on single-cell level, single-cell RNA sequencing is able to identify new or rare cell subsets and construct cell trajectories.These applications are widely applied to researches of cardiovascular diseases.This review summarizes the development of single-cell RNA sequencing and its applications in researches of the pathogenesis of Kawasaki disease, including animal model and acute phase of Kawasaki disease.