Influencing factors of cerebral atherosclerotic stenosis in patients with ischemic stroke in Kashgar / 国际脑血管病杂志

ABSTRACT

Objective:To investigate the related factors of cerebral atherosclerotic stenosis in patients with ischemic stroke in Kashgar.Methods:Patients with ischemic stroke treated in the Department of Neurology, the First People’s Hospital of Kashgar Prefecture from January 2013 to September 2019 were retrospectively enrolled. According to the findings of head and neck angiography, they were divided into without artery stenosis group, only intracranial artery stenosis group, only extracranial artery stenosis group, and intracranial + extracranial artery stenosis group. Demographic and clinical data were compared among the groups. Multivariate logistic regression analysis was used to determine the independent risk factors for cerebral atherosclerotic stenosis. Results:A total of 2 054 patients with ischemic stroke were enrolled. Their age was 60.73±11.36 years, and 1 213 were men (59.1%). There were 973 patients (47.4%) in the without artery stenosis group, 493 (24.0%) in the only intracranial artery stenosis group, 367 (17.9%) in the only extracranial artery stenosis group, and 221 (10.8%) in the intracranial + extracranial artery stenosis group. The comparison among the groups showed that there were significant differences in age, hypertension, diabetes, coronary heart disease, lymphocyte count, leukocyte count, neutrophil count, blood sodium, blood magnesium, fructosamine, fasting blood glucose, albumin, globulin, low-density lipoprotein cholesterol, apolipoprotein B, apolipoprotein A, hypersensitive C-reactive protein, fibrinogen, and neutrophil-to-lymphocyte ratio. Multivariable logistic regression analysis showed that compared with the without arterial stenosis, older age (odds ratio [ OR] 1.01, 95% confidence interval [ CI] 1.003-1.02; P=0.011) and higher neutrophil count ( OR 1.11, 95% CI 1.06-1.16; P<0.001) were the independent risk factors for intracranial arterial stenosis; older age ( OR 1.04, 95% CI 1.02-1.05; P<0.001), complicated with coronary heart disease ( OR 1.43, 95% CI 1.00-2.04; P=0.048), higher low-density lipoprotein cholesterol ( OR 1.22, 95% CI 1.05-1.42; P=0.011) and fibrinogen (OR 1.26, 95% CI 1.07-1.47; P=0.004) were the independent risk factors for extracranial artery stenosis, and older age ( OR 1.06, 95% CI 1.05-1.08; P<0.001), complicated hypertension ( OR 1.85, 95% CI 1.27-2.69; P=0.001) and diabetes ( OR 1.80, 95% CI 1.22-2.66; P=0.003), higher neutrophil count ( OR 1.10, 95% CI 1.02-1.17; P=0.008), fructosamine ( OR 1.36, 95% CI 1.05-1.78; P=0.022) and low-density lipoprotein cholesterol ( OR 1.24, 95% CI 1.02-1.51; P=0.034) were the independent risk factors for intracranial + extracranial artery stenosis. Conclusion:There are some differences in the risk factors for intracranial and extracranial artery stenosis in patients with ischemic stroke in Kashgar Prefecture.