Role of β-amyloid protein in hypoxic/ischemic brain injury / 中华内分泌外科杂志
Chinese Journal of Endocrine Surgery
;
(6): 375-377, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-954601
ABSTRACT
β-amyloid protein (Aβ) is produced from β-amyloid precursor protein under the action of β-secretase and γ-secretase. Aβ accumulates and aggregates, forms oligomers and fibrils, and deposits in the brain, leading to functional neuronal death and cognitive impairment. β- amyloid protein induces inflammatory response, oxidative stress, free radical damage, calciumion disorder and so on, resulting in neuronal necrosis and apoptosis. Recent studies show that β-amyloid also plays an important role in hypoxia/ischemic brain injury. We review the mechanism of β-amyloid protein in hypoxic/ischemic brain injury.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Endocrine Surgery
Year:
2022
Type:
Article
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