Research progress on the role of NLRP3 in the immune inflammation of the " lung-brain axis" of bronchial asthma / 中华实用儿科临床杂志

ABSTRACT

Bronchial asthma is the most common chronic disease in childhood.In clinical diagnosis and treatment, it is found that some children with asthma often have neuropsychiatric disorders of different severity, such as autism spectrum disorders, attention deficit-hyperactivity disorders, panic disorders and anxiety, which render the prognosis and treatment of asthma difficult.Some reports suggest that the " lung-brain axis" of bronchial asthma is related to the outbreak of inflammation-related mechanisms.A new idea to improve bronchial asthma with neuropsychiatric diseases may be inhibiting the release of inflammatory factors and blocking lung-brain inflammation communication.As one of the more thoroughly studied inflammasome family members, NOD-like receptor pyrin domain-containing protein 3 (NLRP3) is widely involved in the mechanisms of neuroinflammation and bronchial asthma attacks.In this article, the role of NLRP3 in the " lung-brain axis" immune inflammation mechanism of bronchial asthma is reported, which may provide new ideas for the diagnosis, treatment and research of bronchial asthma and neuropsychiatric comorbidities.