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Noxious electrical stimulation of the pelvic floor and vagina induces transient voiding dysfunction in a rabbit survival model of pelvic floor dystonia
Korean Journal of Urology ; : 837-844, 2015.
Article in English | WPRIM | ID: wpr-95481
ABSTRACT

PURPOSE:

Existing data supports a relationship between pelvic floor dysfunction and lower urinary tract symptoms. We developed a survival model of pelvic floor dysfunction in the rabbit and evaluated cystometric (CMG), electromyographic (EMG) and ambulatory voiding behavior. MATERIALS AND

METHODS:

Twelve female adult virgin rabbits were housed in metabolic cages to record voiding and defecation. Anesthetized CMG/EMG was performed before and after treatment animals (n=9) received bilateral tetanizing needle stimulation to the pubococcygeous (PC) muscle and controls (n=3) sham needle placement. After 7 days all animals were subjected to tetanizing transvaginal stimulation and CMG/EMG. After 5 days a final CMG/EMG was performed.

RESULTS:

Of rabbits that underwent needle stimulation 7 of 9 (78%) demonstrated dysfunctional CMG micturition contractions versus 6 of 12 (50%) after transvaginal stimulation. Needle stimulation of the PC musculature resulted in significant changes in basal CMG pressure, precontraction pressure change, contraction pressure, interval between contractions and postvoid residual; with time to 3rd contraction increased from 38 to 53 minutes (p=0.008 vs. prestimulation). Vaginal noxious stimulation resulted in significant changes in basal CMG pressure and interval between contractions; with time to 3rd contraction increased from 37 to 46 minutes (p=0.008 vs. prestimulation). Changes in cage parameters were primarily seen after direct needle stimulation.

CONCLUSIONS:

In a majority of animals, tetanizing electrical stimulation of the rabbit pelvic floor resulted in voiding changes suggestive of pelvic floor dysfunction as characterized by a larger bladder capacity, longer interval between contractions and prolonged contraction duration.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Urination / Urine / Vagina / Urinary Bladder / Urinary Retention / Pelvic Floor / Disease Models, Animal / Dystonia / Electric Stimulation / Electromyography Limits: Animals Language: English Journal: Korean Journal of Urology Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Urination / Urine / Vagina / Urinary Bladder / Urinary Retention / Pelvic Floor / Disease Models, Animal / Dystonia / Electric Stimulation / Electromyography Limits: Animals Language: English Journal: Korean Journal of Urology Year: 2015 Type: Article