Depression and Quality of Life in Patients with Systemic Lupus Erythematosus
Journal of Rheumatic Diseases
;
: 346-355, 2015.
Article
in English
| WPRIM
| ID: wpr-95504
ABSTRACT
OBJECTIVE:
The objective of this study is to examine the prevalence of depression and its related factors including quality of life, brain-derived neurotrophic factor (BDNF), and vitamin D in patients with systemic lupus erythematosus (SLE).METHODS:
Depression was assessed using the center for epidemiologic studies depression (CES-D) scale. Disease activity, disease-related organ damage, the EuroQol-5 dimensions (EQ-5D), sociodemographic features, and laboratory tests including serum vitamin D level were surveyed. Serum BDNF was measured using an enzyme-linked immunosorbent assay.RESULTS:
Depression was observed in 22.8% of 180 SLE patients (n=41). Patients with marital status of single/divorced/separated/widowed, a higher patient global assessment (PGA) score, and extreme pain/discomfort showed significant association with depression. The EQ-5D index showed negative correlation with CES-D score (r=-0.56, p<0.05). In each EQ-5D dimension, depression showed significant association with moderate to severe problems in self-care and usual activities, and extreme pain/discomfort. Serum BDNF levels were not associated with depression (p=0.75) but associated with SLE disease activity index (SLEDAI; r=-0.21, p<0.05). Serum vitamin D levels were not associated with depression (p=0.60) but showed negative correlation with SLEDAI (r=-0.23, p<0.05) and mean glucocorticoid dose over the previous 3 months (r=-0.21, p<0.05) after adjustment for use of vitamin D supplement.CONCLUSION:
Depression was prevalent in patients with SLE and was associated with low quality of life, and a higher PGA but not with SLEDAI. Serum BDNF and vitamin D levels were not associated with depression but showed snegative correlation with SLEDAI.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Self Care
/
Vitamin D
/
Enzyme-Linked Immunosorbent Assay
/
Epidemiologic Studies
/
Prevalence
/
Marital Status
/
Brain-Derived Neurotrophic Factor
/
Depression
/
Lupus Erythematosus, Systemic
Type of study:
Observational study
/
Prevalence study
Limits:
Humans
Language:
English
Journal:
Journal of Rheumatic Diseases
Year:
2015
Type:
Article
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