Analgesic efficacy of dexmedetomidine combined with dizosine after lumbar internal fixation and its effects on hyperalgesia / 中国基层医药

ABSTRACT

Objective:To investigate the analgesic efficacy of dexmedetomidine combined with dizosine after lumbar internal fixation and its effects on hyperalgesia.Methods:Seventy-two patients who underwent lumbar internal fixation in General Hospital of Armed Police and Marine Police between April 2018 and June 2019 were included in this study. They were randomly assigned to undergo either flurbiprofen axetil and dizosine administration (control group) or dexmedetomidine and dizosine (observation group) for postoperative analgesia. Mechanical pain, degree of postoperative pain, and incidence of complications were recorded in each group.Results:At 6, 24 and 48 hours after surgery, peri-wound pain threshold in the observation group was (119.52 ± 20.42) points, (120.19 ± 17.44) points, (120.94 ± 20.73) points, respectively, which were significantly higher than (108.42 ± 15.24) points, (107.63 ± 16.83) points, (108.47 ± 17.82) points in the control group ( t = 0.01, 0.00, 0.01, all P < 0.05). At 24 and 48 hours after surgery, forearm pain threshold in the observation group was (109.93 ± 15.87) points and (110.79 ± 22.85) points, respectively, which were significantly higher than (97.07 ± 16.49) points and (95.63 ± 24.06) points ( t = 3.37, 2.74, both P < 0.05). There was no significant difference in Ramsay Sedation Scale score between the two groups ( P > 0.05). There was no significant difference in the dose of dizosine used within 48 hours after surgery between the two groups ( P > 0.05). The incidence of postoperative complications in the observation group was significantly lower than that in the control group [8.33% (3/36) vs. 27.78% (10/36), χ2 = 4.60, P < 0.05]. Conclusion:Dexmedetomidine combined with dizosine exhibits obvious analgesic efficacy after lumbar internal fixation. The combined therapy can effectively prevent hyperalgesia with a low incidence of comphications.