Butorphinol for intravenous patient-controlled analgesia after laparoscopic gynecological surgery / 中国基层医药

ABSTRACT

Objective:To investigate the analgesic effects of butorphinol used in intravenous patient-controlled analgesia after laparoscopic gynecological surgery.Methods:Ninety-eight patients who underwent laparoscopic gynecological surgery in Linhai First People's Hospital between March 2018 and November 2019 were included in this study. They were randomly divided into control and observation groups, with 49 patients per group. After surgery, intravenous patient-controlled analgesia with either ondansetron (control group) or ondansetron combined with butorphanol (observation group). At 2, 12 and 24 hours after surgery, visual analogue scale score and Ramsay sedation scale score were compared between the two groups. Heart rate, systolic blood pressure, and respiratory rate at 0 and 30 minutes after surgery were compared between the two groups. The incidences of postoperative adverse reactions were compared between the two groups.Results:At 2, 12 and 24 hours after surgery, visual analogue scale scores in the observation group were (1.27 ± 0.50) points, (2.24 ± 0.63) points, and (1.71 ± 0.55) points respectively, which were significantly lower than (1.52 ± 0.47) points, (3.20 ± 0.58) points, (2.23 ± 0.59) points in the control group ( t = 2.55, 7.84, 4.51, all P < 0.05). At 2, 12 and 24 hours after surgery, Ramsay sedation scale scores in the observation group were (4.22 ± 0.41) points, (3.22 ± 0.43) points, and (3.02 ± 0.31) points, respectively, which were significantly higher than (4.02 ± 0.32) points, (3.01 ± 0.27) points, (2.73 ± 0.35) points in the control group ( t = -2.69, -2.89, -4.34, all P < 0.05). There were no significant differences in heart rate, systolic blood pressure, and respiratory rate measured at 0 and 30 minutes after surgery between the two groups (all P > 0.05). There were no significant differences in use of pethidine and the incidence of adverse reactions between the two groups (both P > 0.05). Conclusion:Butorphinol helps improve the analgesic and sedative effects after laparoscopic gynecological surgery and has little impact on patient's breathing and circulation.