Clinical efficacy of endovascular stent therapy for treatment of lower extremity atherosclerotic occlusive disease in 40 patients / 中国基层医药

ABSTRACT

Objective:To investigate the short-term and long-term efficacy of endovascular stent therapy for lower extremity atherosclerotic occlusive disease.Methods:Eighty patients with lower extremity atherosclerotic occlusive disease who received treatment in Lishui Central People's Hospital from January 2020 to January 2021 were included in this study. They were randomly divided into control and observation groups, with 40 patients in each group. The control group received lower extremity artery bypass grafting, and the observation group received endovascular stent therapy. Clinical efficacy, ankle-brachial index, claudication distance, blood flow dynamics of dorsalis artery, nerve conduction velocity of the lower extremities, and postoperative complications were compared between the two groups in the short-term and 1-year follow-ups.Results:Total response rate in the observation group was 87.5% (35/40), which was significantly higher than 67.5% (27/40) in the control group ( Z = 2.00, P < 0.05). At 1-year follow-up, total response rate in the observation group was 70.0% (28/40), which was slightly, but not significantly, higher than 47.5% (19/40) in the control group ( Z = 1.77, P > 0.05). After treatment, the ankle-brachial index and claudication distance in the observation group were significantly higher than those in the control group ( t = 3.34, 8.30, both P < 0.001). The diameter, peak velocity and blood flow of dorsal foot artery in the observation group were significantly superior to those in the control group ( t = 6.98, 4.46, 5.95, all P < 0.001). Lower extremity nerve conduction velocity in the observation group was significantly higher than that in the control group ( t = 3.01, 3.70, both P < 0.05). The incidence of postoperative complications in the observation group was slightly, but not significantly, lower than that in the control group [5.0% (2/40) vs. 15.0% (6/40), P > 0.05]. Conclusion:Compared with lower extremity artery bypass grafting, endovascular stent therapy has good short-term and long-term efficacy in the treatment of lower extremity atherosclerotic occlusive disease. Endovascular stent therapy can increase ankle-brachial index and claudication distance, improve the hemodynamic indexes of dorsalis pedis artery, increase lower extremity nerve conduction velocity and has a few complications.