Analysis and prospect of potential value of fecal microbiota transplantation in the treatment of short bowel syndrome / 中国综合临床

ABSTRACT

Short bowel syndrome (SBS) is a series of clinical syndromes caused by the reduction of effective functional area of small intestine for different reasons.Due to the changes of intestinal function and internal environment, SBS can further lead to intestinal mucosal barrier damage, enterogenous liver damage, abnormal bile acid metabolism and so on, which seriously affects the clinical outcome and prognosis of patients. Fecal microbiota transplantation is the transplantation of normal functional bacteria in feces into patients' intestines to help restore and rebuild the balance of intestinal flora. It has been successfully used in the treatment of intestinal and extraintestinal diseases. This paper reviews and prospects the potential value of fecal bacteria transplantation in the treatment of SBS for D-lactic acidosis, intestinal rehabilitation and liver damage associated with intestinal failure, in order to provide new clinical ideas for the treatment of SBS patients.