Study on the correlation between radiation dose and breast compression thickness and density in full-field digital mammography combined with digital breast tomosynthesis / 中华放射医学与防护杂志

ABSTRACT

Objective:To compare and analyze the relationship between average glandular dose (AGD) and breast density and compression thickness in digital breast tomosynthesis(DBT)/full-field digital mammography(FFDM), and to explore the optimal selection and application of imaging parameters for different types of breast (thickness and density) in specific situations.Methods:The clinical data of 229 cases of breast Combo (DBT+ FFDM) were retrospectively analyzed. The compression thickness, AGD, kVp and type of quantified breast density (Q_abd) of CC and MLO view were collected respectively. The relationship between the AGD and the breast compression thickness and Q_abd density classification was analyzed.Results:There was a positive correlation between AGD and compression thickness (CC r =0.55, 0.53, P< 0.001; MLO r =0.62, 0.48, P< 0.001) and breast density(CC r =0.36, 0.39, P< 0.001; MLO r =0.16, 0.30, P < 0.001) in DBT/FFDM. The difference between groups for AGD was little in CC of DBT, but significant in CC of FFDM(groups by thickness, CC F =35.29, 31.32, P<0.005; MLO F =44.83, 27.02, P<0.005; groups by Q_abd, CC F =18.68, 19.76, P<0.005, MLO F=4.58, 10.52, P<0.005); the breast Q_abd was inversely proportion to the mean compression thickness (CC F =16.28, P<0.005; MLO F =17.81, P<0.005). At the same time, the interaction effect on AGD between the breast density and thickness was considered, and only for the MLO in FFDM mode they had an interaction on AGD ( F =3.16, P =0.005). Conclusions:The cumulative dose of DBT and FFDM may increase the radiation risk. Single-view CC/MLO-DBT or CC/MLO-(DBT+ FFDM)+ single-view MLO/CC-FFDM mode is preferred for mammography, which plays a positive role in radiation risk reduction.