Research progress on rodent frailty models / 中华老年医学杂志

ABSTRACT

Frailty is a geriatric syndrome characterized by declines in multisystem functions, decreased functional reserve, and increased vulnerability to adverse health events, and affects the quality of life in older adults.However, the underlying mechanisms of frailty are still unclear.Rodents share homology with humans and are commonly used as animal models to study human diseases.Rodent frailty models can promote frailty research and intervention in humans.We reviewed research progress on rodent frailty models in this article.