Metabolic significance of non-alcoholic fatty liver disease in non-obese adults / 대한내과학회지
Korean Journal of Medicine
;
: 488-495, 2002.
Article
in Korean
| WPRIM
| ID: wpr-95732
ABSTRACT
BACKGROUND:
It is well known that non-alcoholic fatty liver disease is associated with metabolic syndrome such as obesity, type II diabetes mellitus, dyslipidemia. Non-alcoholic fatty liver disease is frequently found in non-obese adults, but the meaning of it is unknown. So we studied the association of non-alcoholic fatty liver disease in non-obese adults and metabolic abnormalities.METHODS:
We examined 779 Korean adults above 30 years old (274 men, 505 women) participating in medical check-up in Health Promotion Center. Hepatitis B and C serologies were negative, and average weekly alcohol intake was or=25 kg/m2, n=348) group (65.5 vs 32.3%, p<0.05). Compared with obese group, waist circumference, waist hip ratio, body fat, impaired fasting serum glucose, total cholesterol, HDL-cholesterol, total cholesterol to HDL-cholesterol ratio, fasting insulin, proinsulin, HOMA-IR and HOMA-beta were significantly different in non-obese, non-alcoholic fatty liver group. After multiple regression analysis, waist circumference was associated with non-alcoholic fatty liver disease in non-obese individuals. Odd ratios of insulin resistance in non-obese, non-alcoholic fatty liver group were 5.8 (CI 3.1~10.9).CONCLUSION:
The frequency of non-alcoholic fatty liver disease was very high in non-obese adults and well associated with central obesity and insulin resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physical Examination
/
Proinsulin
/
Blood Glucose
/
Insulin Resistance
/
Body Mass Index
/
Adipose Tissue
/
Cholesterol
/
Ultrasonography
/
Fasting
/
Waist-Hip Ratio
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Korean
Journal:
Korean Journal of Medicine
Year:
2002
Type:
Article
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