Mental illness and risk of developing obstructive sleep apnea: a two-sample Mendelian randomization study / 中华老年医学杂志
Chinese Journal of Geriatrics
;
(12): 1146-1149, 2022.
Article
in Chinese
| WPRIM
| ID: wpr-957354
ABSTRACT
Objective:
A two-sample Mendelian randomized study was used to investigate the relationship between psychiatric disorders and the risk of developing obstructive sleep apnea(OSA).Methods:
Genetic variations in bipolar disorder, depression, Alzheimer's disease and schizophrenia were used as instrumental variables and data from genome-wide association studies of OSA patients from the Finngen Consortium were used.In this study, inverse variance weighted method was used as the main analysis method, and three sensitivity analyses including weighted median analysis, MR-Egger regression analysis and MR-PRESSO analysis were jointly applied.Results:
Higher genetic predisposition for depression and bipolar disorder increased the risk of developing OSA, the odds ratio is 1.18(95% CI 1.02-1.37, P=0.026)and 1.06(95% CI 1.01-1.12, P=0.038)for each unit increase with log-transformed odds ratios of depression and bipolar disorder, respectively.Genetic susceptibility to Alzheimer's disease and schizophrenia was not associated with the risk of developing OSA.Conclusions:
This study suggests that a higher genetic predisposition for depression and bipolar disorder may lead to a higher risk of developing OSA.OSA and psychiatric disorders such as depression and bipolar disorder have a high incidence in the elderly, however, their causal effects still need to be studied.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Geriatrics
Year:
2022
Type:
Article
Similar
MEDLINE
...
LILACS
LIS