The effect of triiodothyronine on the heart: A brief review / 中华内分泌代谢杂志

ABSTRACT

Thyroid hormone receptors are expressed in myocardium and vascular endothelial tissue and are very sensitive to changes in circulating thyroid hormone (TH) levels, especially triiodothyronine (T 3), therefore small changes can adversely affect the cardiovascular system. Evidence from several studies in recent years supports the association between abnormal thyroid function at the time of cardiovascular event and subsequent adverse cardiovascular outcomes. Several clinical trials have found that treatment of subclinical thyroid disease improves cardiovascular risk factors, suggesting the potential benefit of TH therapy in reducing cardiovascular outcome events. This article reviews the relationship between T 3 and cardiovascular disease and its physiological effects on the heart, as well as the therapeutic potential of T 3 in heart failure and acute myocardial infarction.