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Gene therapy for recessive dystrophic epidermolysis bullosa / 中华皮肤科杂志
Chinese Journal of Dermatology ; (12): 739-743, 2022.
Article in Chinese | WPRIM | ID: wpr-957710
ABSTRACT
Recessive dystrophic epidermolysis bullosa (RDEB) is caused by loss-of-function mutations in the COL7A1 gene encoding the α-1 chain of type Ⅶ collagen, leading to reduced or absent expression of basement membrane type Ⅶ collagen (C7) . Currently, there is no effective treatment for this rare disease, and the management is mainly palliative and supportive. Gene therapy is expected to be an effective treatment of RDEB. This review summarizes current strategies of gene therapy in clinical trials for RDEB, as well as their progress, pros and cons, and prospects.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Dermatology Year: 2022 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Dermatology Year: 2022 Type: Article