Surgical therapy for gallbladder carcinoma: experiences in 115 cases / 中华普通外科杂志

ABSTRACT

Objective:To investigate the clinical efficacy and prognostic factors of surgical resection for gallbladder carcinoma.Methods:The clinicopathological data of 115 patients with gallbladder cancer treated by surgical operation in the First Affiliated Hospital of USTC (Anhui Provincial Hospital) from Dec 2015 to Dec 2020 were retrospectively analyzed. Follow-up was ended on Sep 30, 2021.Results:Tumor detection rate by ultrasonography, CT and MRCP were 64.7% (55/85), 83.3% (55/66) and 48.4% (31/64), respectively. All patients underwent surgical exploration, among which 76 patients underwent radical surgery and 39 did palliative surgery. Patients were followed up for 10-69 months, and the median survival time was 22 months. The overall survival rates at 1, 3 and 5 years were 67.4%, 31.2% and 28.4%, respectively. Univariate analysis showed that the degree of tumor differentiation, CA19-9, tumor size, nerve invasion, vascular invasion, lymph node metastasis, and T stage were correlated with the prognosis. Multivariate analysis showed that increased CA19-9, T stage, and lymph node metastasis were independent risk factors of the prognosis.Conclusion:Early diagnosis of gallbladder carcinoma is difficult, radical surgical treatment is preferred, and the overall prognosis is poor, CA19-9, T staging and lymph node metastasis are closely related to the prognosis.