Focusing on new research and clinical management of gastrointestinal symptoms in Parkinson′s disease / 中华神经科杂志

ABSTRACT

Gastrointestinal symptoms are common nonmotor symptoms of Parkinson′s disease, which are related closely to occurrence and progress of Parkinson′s disease, as well as throughout its whole process. For example, constipation can be an important symptom in prodromal stage of Parkinson′s disease, and gastroparesis would weaken the effect of drug by interfering pharmacokinetics. However, insufficient attention has been paid to the gastrointestinal symptoms of Parkinson′s disease presently, and there are few effective treatments, which compromise the quality of patients′ life greatly. The intervention focus on gut-brain axis, microbiota and gastrointestinal barrier may play a positive role in improving gastrointestinal symptoms and delaying the process of Parkinson′s disease.